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Year : 2016  |  Volume : 53  |  Issue : 4  |  Page : 258-262

Hormonal profile and clinical characteristics of epileptic females with abnormal ovarian morphology

1 Department of Neurology, Cairo University, Cairo, Egypt
2 Department of Radiology, Cairo University, Cairo, Egypt

Correspondence Address:
Asmaa M Ebraheim
Department of Neurology, Cairo University, Cairo
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1110-1083.202388

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Background Women with epilepsy (WWE) tend to have ovarian echographic abnormalities, raising concerns about an interaction between the brain and the ovaries. Objective This study aims to determine the relationship between abnormal ovarian follicular morphology as detected by ultrasonography (US) and clinical features, hormonal profile, and antiepileptic drugs (AEDs) in epileptic females. Participants and methods WWE who attended Kasr Al-Ainy Epilepsy Clinic and fulfilled the inclusion criteria were recruited and assessed clinically. Transabdominal US of the ovaries and the uterus was performed; in addition, serum levels for luteinizing hormone (LH), follicle-stimulating hormone, estradiol, testosterone, and fasting insulin were determined for all the participants. Thirteen WWE who had ovarian echographic abnormalities were compared with 67 epileptic females with normal ovarian US. Results Significantly elevated LH was detected in patients with ovarian morphologic abnormality compared with the control group. The clinical parameters, the frequency of use of different AEDs, and the mean values of the other hormones were comparable in both groups. Conclusion Elevated LH in patients with an ovarian echographic abnormality points to altered gonadotropin secretion in these patients, which could be explained by the effect of epileptic discharges on the hypothalamus, but not the use of AEDs.

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