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ORIGINAL ARTICLE
Year : 2016  |  Volume : 53  |  Issue : 3  |  Page : 174-178

Effects of vitamin D deficiency on the relapse, severity, and disability of multiple sclerosis


1 Department of Neurology, Faculty of Medicine, Mansoura University, Mansoura, Egypt
2 Department of Neurology, Misr University for Sciences and Technology, Giza, Egypt

Correspondence Address:
Mohammed El-Sherif
Department of Neurology, Faculty of Medicine, Mansoura University, Mansoura 35516, Dakahlia
Egypt
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Source of Support: None, Conflict of Interest: None


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Background Multiple sclerosis (MS) is a long-standing inflammatory disease of the white matter and affects more than two million people worldwide. Upcoming evidence proposed that 25-hydroxy-vitamin D3 (25HVD3) deficiency could be one of the most crucial environmental elements for the pathogenesis of MS. Objective The aim of this study was to compare 25HVD3 levels in MS patients and controls and to detect the association with relapse, severity, and disability in MS patients. Patients and methods Mansoura Neurology Department data sheet was collected and all patients were assessed using the Expanded Disability Status Scale (EDSS) at the onset. 25HVD3 levels in the blood were evaluated for all patients and controls using the chemiluminescent immunoassay test. Results A total of 50 MS patients were included in this work and matched with 25 controls. There was a statistically significantly lower mean serum 25HVD3 level in MS patients in comparison with the controls (20.5 ± 16.8 and 42.9 ± 17.9 ng/ml, respectively; P = 0.002). In addition, there was a statistically significantly lower level of 25HVD3 (18.4 ± 17.7) in severe cases of MS (EDSS ≥ 6; P < 0.05) with certain significant clinical features such as older age (P < 0.001) and longer disease duration (P < 0.001). The incidence of 25HVD3 deficiency (<20 ng/ml) in MS patients was 60%. Conclusion Our results showed that there is an inverse correlation between 25HVD3 level and EDSS score. In addition, lower 25HVD3 levels are associated with increased relapse risk in MS.


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