• Users Online: 35
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
Year : 2016  |  Volume : 53  |  Issue : 2  |  Page : 84-88

Helicobacter pylori infection in Egyptians with Parkinson's disease: incidence and the effect on motor fluctuation and response to levodopa

1 Department of Neurology, Mansoura University, Cairo, Egypt
2 Department of Internal Medicine, Mansoura University, Cairo, Egypt
3 Department of Neurology, Misr University for Sciences and Technology, Cairo, Egypt

Correspondence Address:
Mohammed El-Sherif
Department of Neurology, Mansoura Faculty of Medicine, Mansoura University, Mansoura 35516, Dakahlia
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1110-1083.183408

Rights and Permissions

Background Gastrointestinal tract infection with Helicobacter pylori (HP) can inhibit levodopa (LD) in Parkinson's disease (PD) patients, leading to motor fluctuation. Objectives The aim of this study was to identify the incidence of HP in PD patients compared with healthy controls and its effect on motor fluctuation, response to treatment, and quality of life. Patients and methods Serum IgG Abs against HP urease were detected using enzyme-linked immunosorbent assay. We compared the incidence of HP infection in PD patients and controls. We compared PD patients with positive HP (PD positive) and PD patients with negative HP infection (PD negative) with regard to clinical features, the Unified PD Rating Scale (UPDRS) scores, Hoehn and Yahr (H and Y) stages, PD Questionnaire for the quality of life (PD-Q39), and PD Nonmotor Symptoms Questionnaire (PD NMSQ). Results Fifty Egyptians with PD were included. Forty-six percent of patients were HP positive compared with 20% in the control group; the difference was statistically significant (P = 0.043). In PD-positive patients, the total UPDRS and PD-Q39 scores were significantly higher in comparison with PD-negative patients (P < 0.005 and P < 0.001, respectively). The differences were not significant with regard to the total PD NMSQ score and H and Y stages between the two groups of patients. The LD onset period was significantly greater in PD-positive patients by nearly 14 min in comparison with PD-negative patients. There was a significantly prolonged on-duration time in PD-positive patients in comparison with PD-negative patients. Conclusion There is a high incidence of HP infection in PD. HP affects the response to LD and can deteriorate motor manifestations and the quality of life.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded332    
    Comments [Add]    
    Cited by others 2    

Recommend this journal