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Year : 2016  |  Volume : 53  |  Issue : 1  |  Page : 60-63

Value of mean platelet volume as a predictor of functional outcome in different types of ischemic stroke

1 Department of Neurology, Ain Shams University, Cairo, Egypt
2 Department of Clinical Pathology, Ain Shams University, Cairo, Egypt
3 Department of Neurology, Helwan University, Cairo, Egypt

Correspondence Address:
Magdy A Mostafa
Department of Neurology, Ain Shams University, Cairo
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1110-1083.176375

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Background Platelets play an important role in the pathogenesis of ischemic stroke. Mean platelet volume (MPV) values in association with both thrombosis and inflammation have become a point of interest in the last few decades, and some studies have reported MPV values significantly higher in patients with stroke compared to controls. Objective The aim of this study was to investigate the association between MPV and the functional outcome of different types of acute ischemic brain stroke. Patients and methods Ninety patients with the diagnosis of first-ever acute ischemic stroke were included. Those patients were divided into three equal groups. The first includes patients with lacunar stroke, the second includes patients with large vessel disease, and the third includes cardioembolic stroke patients. They were 35 female (39%) and 55 males (61%). Their age ranged from 29 to 87 years with median value 60 years. MPV was measured on admission. All patients were followed for 3 months then functional outcome was measured using the modified Barthel index. Results There was a significant inverse relation between MPV and modified Barthel index score (P < 0.01) only in patients with lacunar stroke. Regarding the other two groups, such correlation is not present. Conclusion MPV may be used as early predictor of outcome only in patients with small vessels disease.

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